Description

4-o-Methyl-D-Glucuronic Acid is a key methylated derivative of D-glucuronic acid, serving as a vital building block and intermediate in advanced organic synthesis and biochemical research. Its primary value lies in its role as a precursor for synthesizing complex carbohydrates, glycoconjugates, and specialized polymers where controlled methylation is required. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors developing novel therapeutics, diagnostic agents, and advanced materials.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of novel glycosylated drugs, prodrugs, and targeted therapeutic agents.
• Biochemical Research: Used as a standard and substrate in enzymatic studies, metabolic pathway analysis, and glycobiology research.
• Carbohydrate Chemistry: Serves as a key building block for the chemical and enzymatic synthesis of complex oligosaccharides and polysaccharide analogs.
• Polymer Science: Monomer for developing specialized biodegradable polymers, hydrogels, and functional materials with tailored properties.
• Analytical Standard: High-purity grade used as a reference standard in HPLC, LC-MS, and NMR for quality control and method development.
• Glycoconjugate Synthesis: Essential for creating labeled probes, vaccine components, and diagnostic tools that require specific sugar acid motifs.

Basic Information

Product Name	4-o-Methyl-D-Glucuronic Acid
CAS No.	4120-73-4
Molecular Formula	C7H12O7
Molecular Weight	208.17 g/mol
Synonyms	4-O-Methyl-D-glucuronic acid; (2S,3S,4S,5R)-2,3,4-Trihydroxy-5-[(1R)-1-hydroxy-2-oxoethoxy]oxane-2-carboxylic acid; 4-O-Methylglucuronic Acid; Methylglucuronic Acid; 4-OMe-GlcA; D-4-O-Methylglucuronic Acid
EINECS	223-915-6

Quality Control

Every batch of 4-o-Methyl-D-Glucuronic Acid is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing specifications such as assay, optical rotation, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable performance for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation; consider the use of desiccants. For long-term storage, inert atmosphere packaging is recommended.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]²⁰D	+60° to +70° (c=1 in H₂O)
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.