Description

Methyl β-Neuraminic Acid, Methyl Ester CAS NO 497-43-8 is a key protected derivative of N-acetylneuraminic acid (sialic acid), a critical monosaccharide in glycobiology. This compound serves as a vital synthetic intermediate and research standard for studying sialic acid metabolism, glycosylation, and pathogen-host interactions. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who are developing glycoconjugate vaccines, antiviral agents, and novel therapeutic platforms.

Application

• Glycoconjugate Synthesis: A crucial protected building block for the chemical and enzymatic synthesis of complex oligosaccharides, glycopeptides, and glycolipids.
• Pharmaceutical Intermediates: Used in the research and development of sialidase inhibitors, antiviral drugs, and anti-inflammatory agents targeting sialic acid pathways.
• Biochemical Research: Serves as a standard and substrate for studying sialidases (neuraminidases), sialyltransferases, and other enzymes involved in sialic acid biology.
• Diagnostic Reagent Development: Employed in the production of reagents and assays for detecting pathogens like influenza viruses that utilize neuraminidase.
• Vaccine Development: A key intermediate in the development of next-generation glycoconjugate vaccines against bacterial pathogens such as *Streptococcus pneumoniae* and *Neisseria meningitidis*.
• Cell Biology Studies: Used to investigate the role of sialic acids in cell signaling, adhesion, and immune recognition.

Basic Information

Product Name	Methyl β-Neuraminic Acid, Methyl Ester
CAS No.	497-43-8
Molecular Formula	C12H21NO9
Molecular Weight	323.30 g/mol
Synonyms	Methyl 5-acetamido-3,5-dideoxy-D-glycero-D-galacto-non-2-ulopyranosidonic acid; Methyl (methyl 5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosid)onate; Methyl ester of N-Acetylneuraminic acid methyl glycoside; Methyl N-Acetyl-β-neuraminate; Neu5Ac Methyl Ester; Sialic Acid Methyl Ester Methyl Glycoside; 2-O-Methyl-β-Neu5Ac Methyl Ester
EINECS	207-842-8

Quality Control

Our Methyl β-Neuraminic Acid, Methyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR, MS), to ensure it meets exacting standards for research and synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and specific impurity profiles. We support compliance with relevant guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere after each use to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.