Description

Kynurenic Acid is a naturally occurring tryptophan metabolite and a well-characterized, broad-spectrum antagonist of excitatory amino acid receptors. This compound is of significant interest in biochemical and neurological research due to its role as an endogenous neuroprotectant. It serves as a critical reference standard and active ingredient for researchers and manufacturers in the pharmaceutical, life science, and diagnostic sectors, particularly for studies involving the glutamatergic system and neuroinflammation.

Application

• Neurological Research: Used as a selective antagonist at the glycine site of the N-methyl-D-aspartate (NMDA) receptor and as a non-competitive antagonist of the α7-nicotinic acetylcholine receptor for in vitro and in vivo studies.
• Pharmaceutical Intermediates: Serves as a key building block or reference compound in the development of novel neuroprotective agents and central nervous system (CNS) therapeutics.
• Biochemical Assays: Employed as a standard in HPLC, LC-MS, and other analytical methods for quantifying kynurenine pathway metabolites in biological samples.
• Diagnostic Development: Utilized in the formulation of calibration standards and controls for diagnostic kits targeting metabolic disorders and inflammatory biomarkers.
• Academic & Institutional Research: Fundamental tool for investigating the kynurenine pathway's role in immune regulation, neurodegenerative diseases, and psychiatric conditions.

Basic Information

Product Name	Kynurenic Acid
CAS No.	492-27-3
Molecular Formula	C10H7NO3
Molecular Weight	189.17 g/mol
Synonyms	4-Hydroxyquinoline-2-carboxylic acid; Quinurenic acid; Kynurenate; 2-Carboxy-4-hydroxyquinoline; KYN; Kynureninic acid
EINECS	207-757-8

Quality Control

Our Kynurenic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identification (IR, HPLC), assay (HPLC), and impurity profiling, to ensure it meets the high-purity standards required for research and development. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.