Description

(R,R)-3,4-Dihydroxytetrahydrofuran is a high-value chiral building block and versatile synthetic intermediate. Its significance lies in its rigid, functionalized tetrahydrofuran core, which is a key structural motif in numerous bioactive molecules and pharmaceuticals. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries, particularly for the synthesis of nucleoside analogs, antiviral agents, and complex natural products.

Application

• Pharmaceutical Intermediate: Critical chiral precursor for the synthesis of antiviral drugs, nucleoside analogs, and other active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the development of chiral herbicides, fungicides, and plant growth regulators.
• Fine Chemical Building Block: Serves as a starting material for complex natural product synthesis and specialty chemicals.
• Asymmetric Catalysis Ligand Precursor: Its chiral diol structure can be utilized to develop novel ligands for asymmetric synthesis.
• Polymer Chemistry: Potential monomer for creating functionalized, biodegradable polymers with specific stereochemistry.
• Academic & R&D: Valuable reagent for methodological development in organic synthesis and medicinal chemistry research.

Basic Information

Product Name	(R,R)-3,4-Dihydroxytetrahydrofuran
CAS No.	473-85-8
Molecular Formula	C4H8O3
Molecular Weight	104.10 g/mol
Synonyms	(2R,3R)-2,3-Dihydroxytetrahydrofuran; (R,R)-Tetrahydro-2,3-furandiol; (2R,3R)-Tetrahydrofuran-2,3-diol; (2R,3R)-2,3-Dihydroxytetrahydrofuran; L-Threo-tetrahydro-2,3-furandiol; (2R,3R)-2,3-Furandiol, tetrahydro-; (R,R)-THF diol
EINECS	207-471-0

Quality Control

Our (R,R)-3,4-Dihydroxytetrahydrofuran is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, guaranteeing traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures will lead to degradation. Keep the container sealed after each use.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.