Description

N,n-Dimethyl-L-Proline is a high-purity, non-proteinogenic amino acid derivative of significant interest in advanced organic synthesis. This compound serves as a crucial chiral building block and ligand, enabling the precise construction of complex molecular architectures. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for applications ranging from asymmetric catalysis to the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and metabolic diseases.
• Asymmetric Catalysis: Employed as a ligand or catalyst component in enantioselective reactions, such as hydrogenations and cross-couplings, to produce single-enantiomer compounds.
• Agrochemical Research: Used in the development of novel, chiral herbicides, fungicides, and plant growth regulators with improved efficacy and environmental profiles.
• Peptidomimetics & Bioactive Molecule Design: Incorporated into peptide backbones to create stable, conformationally restricted analogs for drug discovery and biochemical probes.
• Coordination Chemistry: Acts as a chelating agent for metal ions, useful in creating complexes for material science and diagnostic applications.
• Academic & Process Chemistry Research: A valuable reagent for methodological development and scaling up synthetic routes in both academic and industrial R&D laboratories.

Basic Information

Product Name	N,n-Dimethyl-L-Proline
CAS No.	471-87-4
Molecular Formula	C7H13NO2
Molecular Weight	143.18 g/mol
Synonyms	(S)-1,2-Dimethylpyrrolidine-2-carboxylic acid; L-Proline, N,N-dimethyl-; N,N-Dimethyl-L-proline; (2S)-1,2-Dimethylpyrrolidine-2-carboxylic acid; 1,2-Dimethyl-L-proline; N,N-Dimethylproline; (S)-N,N-Dimethylproline; Dimethylproline
EINECS	207-439-5

Quality Control

Our N,n-Dimethyl-L-Proline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, chiral purity (enantiomeric excess), and identity confirmation. A Certificate of Analysis (COA) detailing all specifications and test results is supplied with every batch to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (ee)	≥ 99.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.