Description

Humulon CAS NO 469-02-3 is a key alpha acid compound primarily derived from hops (Humulus lupulus). This compound is highly valued for its role as a precursor to iso-alpha acids, which are essential for imparting the characteristic bitter flavor and aroma to beer. It is a critical raw material for breweries, flavor and fragrance houses, and research institutions focused on natural product chemistry and food science.

Application

• Brewing Industry: Primary application as the main bittering agent in beer production, where it isomerizes during the wort boil.
• Flavor & Fragrance: Used as a natural flavoring agent and a reference standard for bitter taste profiles in food and beverage development.
• Pharmaceutical Research: Investigated for potential bioactive properties, including antimicrobial, anti-inflammatory, and anticancer activities in preclinical studies.
• Analytical Standards: Serves as a high-purity reference standard for quality control and quantification of hop acids in raw materials and finished products via HPLC.
• Nutraceuticals & Supplements: Incorporated into dietary supplements for its potential antioxidant and calming properties.
• Academic & Industrial R&D: Used in chemical synthesis and as a model compound for studying plant secondary metabolites and extraction processes.

Basic Information

Product Name	Humulon
CAS No.	469-02-3
Molecular Formula	C21H30O5
Molecular Weight	362.46 g/mol
Synonyms	Humulone; α-Lupulic acid; α-Bitter acid; (3S,5S,6R)-3,5,6-Trihydroxy-4,6-bis(3-methylbut-2-en-1-yl)-2-(2-methylpropanoyl)cyclohexa-2,4-dien-1-one; 1,3,4,5-Tetrahydroxy-6,6-bis(3-methyl-2-butenyl)-2-(2-methyl-1-oxopropyl)-2,4-cyclohexadien-1-one; NSC 407324; Hop alpha acid
EINECS	207-419-2

Quality Control

Our Humulon is produced and tested under strict quality management systems. We offer grades suitable for research, food, and brewing applications, with typical purity levels exceeding 95% (by HPLC). Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. Specifications can be tailored to meet FCC, Food Grade, or other relevant industry standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label for long-term stability. This product is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to pale brown powder or resin
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Specific Rotation	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.