Description

Orthoformic Acid is a versatile and highly reactive chemical intermediate, primarily valued for its role as a formylating agent and protecting group in complex organic syntheses. Its high volatility and reactivity make it a critical reagent for introducing formyl groups and constructing heterocyclic frameworks under controlled conditions. This compound is essential for research and production in the pharmaceutical, agrochemical, and fine chemical industries, where precise molecular construction is paramount.

Application

• Pharmaceutical Synthesis: Key intermediate in the production of active pharmaceutical ingredients (APIs), particularly for antiviral and antibacterial compounds.
• Agrochemical Manufacturing: Used in the synthesis of advanced pesticides, herbicides, and plant growth regulators.
• Fine Chemical Production: Serves as a crucial building block for dyes, pigments, and complex fragrance molecules.
• Organic Synthesis Reagent: Acts as a formylating agent and a protecting group for alcohols and amines in multi-step laboratory and industrial syntheses.
• Polymer Chemistry: Employed in the modification of polymers and the synthesis of specialized resins.
• Chemical Research: Utilized in academic and industrial R&D for developing new synthetic methodologies and novel compounds.

Basic Information

Product Name	Orthoformic Acid
CAS No.	463-78-5
Molecular Formula	C3H8O3
Molecular Weight	92.09 g/mol
Synonyms	Trimethoxymethane; Methyl Orthoformate; Trihydroxymethane; Orthoformic Acid Trimethyl Ester; Trimethyl Orthoformate; Formic Acid Trimethyl Ester; Trimethoxy Methane; 1,1,1-Trimethoxymethane
EINECS	207-350-3

Quality Control

Our Orthoformic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including Gas Chromatography (GC) and Nuclear Magnetic Resonance (NMR) spectroscopy, to verify identity and purity. A detailed Certificate of Analysis (COA) is available for every shipment, confirming compliance with agreed specifications and industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, containers must be kept tightly sealed when not in use to prevent evaporation and maintain product integrity. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.378 - 1.382
Density (20°C)	1.02 - 1.04 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.