Description

Homogentisic Acid CAS NO 451-13-8 is a key phenolic acid and a crucial intermediate metabolite in the tyrosine degradation pathway. Its significance lies in its role as a biochemical marker and a valuable building block for research into metabolic disorders and antioxidant studies. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science research sectors, particularly for studying alkaptonuria and developing diagnostic assays.

Application

• Biochemical Research: Critical substrate and reference standard for studying the tyrosine metabolic pathway and related inborn errors of metabolism like alkaptonuria.
• Diagnostic Development: Used in the formulation of calibration standards and reagents for clinical diagnostic kits targeting metabolic disorders.
• Pharmaceutical Intermediates: Serves as a precursor or intermediate in the synthesis of specialized fine chemicals and potential therapeutic agents.
• Enzymology Studies: Employed as a specific substrate for enzymes such as homogentisate 1,2-dioxygenase in kinetic and inhibition assays.
• Antioxidant Research: Investigated for its inherent redox properties and role in oxidative stress models within cellular and biochemical studies.
• Academic & Industrial R&D: A fundamental tool for universities, contract research organizations (CROs), and industrial labs focused on metabolism and biochemistry.

Basic Information

Product Name	Homogentisic Acid
CAS No.	451-13-8
Molecular Formula	C8H8O4
Molecular Weight	168.15 g/mol
Synonyms	2,5-Dihydroxyphenylacetic Acid; Alkapton; Homogentisate; 2,5-DHPA; (2,5-Dihydroxyphenyl)acetic Acid; Homogentisic Acid; Melanuric Acid; 1-Hydroxy-5-(carboxymethyl)benzene-1,2-diol
EINECS	207-193-2

Quality Control

Our Homogentisic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, prolonged exposure to light, air, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	~148 - 152 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.