Description

5-Fluoro-4-Hydroxyquinazoline is a high-purity, fluorinated quinazoline derivative, a crucial heterocyclic building block in advanced organic synthesis. Its value lies in its unique molecular scaffold, which is integral to the development of novel pharmacologically active compounds. This intermediate is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for creating new active ingredients and fine-tuning molecular properties.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of tyrosine kinase inhibitors (TKIs) and other targeted cancer therapies.
• Agrochemical Research: Used in the synthesis of novel herbicides and fungicides, leveraging the bioactivity of the quinazoline core.
• Chemical Biology Probe Development: Serves as a foundational structure for creating molecular probes to study enzyme function and cellular signaling pathways.
• Material Science Precursor: Potential building block for advanced organic electronic materials and liquid crystals due to its planar, conjugated structure.
• Academic & Contract Research: Essential for medicinal chemistry programs in universities and CROs (Contract Research Organizations) focused on heterocyclic chemistry.

Basic Information

Product Name	5-Fluoro-4-Hydroxyquinazoline
CAS No.	436-72-6
Molecular Formula	C8H5FN2O
Molecular Weight	164.14 g/mol
Synonyms	4-Hydroxy-5-fluoroquinazoline; 5-Fluoro-4-quinazolinol; 5-Fluoro-4(3H)-quinazolinone; 436-72-6; 5-Fluoro-4-hydroxy-quinazoline; Quinazoline, 5-fluoro-4-hydroxy-; 4-Hydroxy-5-fluorquinazolin
EINECS	Contact for details

Quality Control

Our 5-Fluoro-4-Hydroxyquinazoline is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.