Description

4-(Trifluoromethylsulfonyl)Nitrobenzene is a high-value fluorinated aromatic building block characterized by its electron-withdrawing triflyl and nitro substituents. This compound matters for its critical role in facilitating advanced organic synthesis, particularly in the construction of complex molecules for pharmaceuticals and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially those requiring sulfonamide or fluorinated motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the trifluoromethylsulfonyl group enhances biological activity.
• Material Science: Serves as a precursor for specialty polymers, liquid crystals, and electronic materials due to its strong electron-accepting properties.
• Cross-Coupling Reactions: An effective substrate in palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) for introducing functionalized aryl groups.
• Organic Synthesis Building Block: Employed in nucleophilic aromatic substitution reactions and as a precursor to anilines and other derivatives.

Basic Information

Product Name	4-(Trifluoromethylsulfonyl)Nitrobenzene
CAS No.	432-87-1
Molecular Formula	C7H4F3NO4S
Molecular Weight	255.17 g/mol
Synonyms	1-Nitro-4-(trifluoromethylsulfonyl)benzene; α,α,α-Trifluoro-4-nitrobenzenesulfonamide; 4-Nitro-α,α,α-trifluorobenzenesulfonamide; p-(Trifluoromethylsulfonyl)nitrobenzene; 4-Nitrobenzenesulfonyl fluoride, trifluoro-; Benzene, 1-nitro-4-[(trifluoromethyl)sulfonyl]-; (Trifluoromethanesulfonyl)-4-nitrobenzene
EINECS	207-099-9

Quality Control

Our 4-(Trifluoromethylsulfonyl)Nitrobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.