Description

Phenyl (Trifluoromethyl) Sulfone is a versatile organosulfur compound featuring a sulfone group linked to a phenyl ring and a trifluoromethyl group. This structure imparts unique chemical properties, making it a valuable intermediate and reagent in advanced synthetic chemistry. It is particularly sought after by R&D chemists and process engineers in the pharmaceutical and agrochemical industries for constructing complex molecules and developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring the introduction of sulfone or fluorine-containing motifs for enhanced bioactivity or metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve compound efficacy and environmental profile.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, coatings, and electronic materials with specific thermal or chemical resistance properties.
• Organic Synthesis Reagent: Acts as a versatile reagent in cross-coupling reactions, nucleophilic substitutions, and as a source of the phenylsulfonyl group in complex molecule construction.
• Ligand and Catalyst Development: Employed in the design and synthesis of novel ligands and organocatalysts for asymmetric synthesis and other catalytic processes.

Basic Information

Product Name	Phenyl (Trifluoromethyl) Sulfone
CAS No.	426-58-4
Molecular Formula	C7H5F3O2S
Molecular Weight	210.17 g/mol
Synonyms	(Trifluoromethyl) Phenyl Sulfone; α,α,α-Trifluorotoluene-4-sulfonic Acid Sulfone; Benzenesulfonyl Fluoride, α,α,α-Trifluoro-; 1-Trifluoromethylsulfonylbenzene; Phenyl Trifluoromethyl Sulphone; Phenyl(trifluoromethyl)sulfone; (Trifluoromethyl)sulfonylbenzene; 4-(Trifluoromethyl)phenyl Sulfone
EINECS	207-046-5

Quality Control

Our Phenyl (Trifluoromethyl) Sulfone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	44 - 48 °C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.