Description

4-Fluoro-3-Iodobenzoic Acid is a high-purity, multi-functional halogenated benzoic acid derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both fluorine and iodine substituents, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries, where precise molecular architecture is required.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic cores for bioactivity or as a handle for further functionalization via cross-coupling reactions.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, where the fluorine and iodine atoms can enhance metabolic stability and binding affinity.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorine-containing aromatic compounds used in electronic displays and organic light-emitting diodes (OLEDs) due to its ability to modify electronic properties.
• Cross-Coupling Reactions: The iodine atom is an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Sonogashira couplings, enabling rapid diversification of the benzoic acid scaffold.
• Ligand & Catalyst Development: Utilized in the preparation of specialized ligands for catalysis or as a core structure for metal-organic frameworks (MOFs).
• Chemical Research & Development: A valuable reagent for academic and industrial R&D in medicinal chemistry and material science for structure-activity relationship (SAR) studies.

Basic Information

Product Name	4-Fluoro-3-Iodobenzoic Acid
CAS No.	403-18-9
Molecular Formula	C7H4FIO2
Molecular Weight	266.01 g/mol
Synonyms	3-Iodo-4-fluorobenzoic Acid; Benzoic acid, 4-fluoro-3-iodo-; 4-Fluoro-3-iodobenzoic acid; 403-18-9; 3-Iodo-4-fluorobenzoic acid; 4-Fluoro-3-iodo-benzoic acid; 4-Fluoro-m-iodobenzoic acid; NSC 403018
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-Iodobenzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We can support development projects with custom purity grades and analytical documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be stored away from light as indicated.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Melting Point	Contact for details
Heavy Metals	<20 ppm
Loss on Drying	<0.5%
Residue on Ignition	<0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.