Description

3-Bromo-4,6-Dinitrofluorobenzene is a versatile and highly functionalized aromatic compound, serving as a critical electrophilic intermediate in advanced organic synthesis. Its unique combination of halogen, nitro, and fluorine substituents makes it an indispensable reagent for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. This high-purity building block is essential for research and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for nucleophilic aromatic substitution (SNAr) and cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those containing aryl ethers, aryl amines, or heterocyclic systems via nucleophilic aromatic substitution reactions.
• Agrochemical Synthesis: Used in the manufacture of herbicides, fungicides, and insecticides, where the introduction of the bromo and nitro groups is crucial for biological activity.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands for transition metal catalysis and organocatalysts.
• Dye and Pigment Manufacturing: Acts as an intermediate in the production of high-performance dyes and pigments, leveraging its electron-deficient aromatic ring.
• Polymer and Material Science: Employed to functionalize polymers or create novel monomers for advanced materials with specific electronic or thermal properties.
• Research and Development: A valuable tool in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	3-Bromo-4,6-Dinitrofluorobenzene
CAS No.	400-91-9
Molecular Formula	C6H2BrF N2O4
Molecular Weight	264.99 g/mol
Synonyms	1-Bromo-2-fluoro-3,5-dinitrobenzene; 2-Fluoro-3,5-dinitrobromobenzene; 3-Bromo-2-fluoro-1,5-dinitrobenzene; Benzene, 1-bromo-2-fluoro-3,5-dinitro-; 3,5-Dinitro-2-fluorobromobenzene; 2-Fluoro-3,5-dinitro-1-bromobenzene; Fluorodinitrobromobenzene
EINECS	Contact for details

Quality Control

Our 3-Bromo-4,6-Dinitrofluorobenzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, to meet the stringent requirements of our global customer base in fine chemical synthesis. Certificates of Analysis (COA) detailing purity, identity, and specific impurity limits are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and reducing agents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	92 - 96 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.