Description

N,n-Di-Boc-4-Nitroaniline is a high-purity, protected aniline derivative widely used as a critical synthetic intermediate in advanced organic chemistry. This compound is essential for researchers and manufacturers requiring precise control over molecular structure in complex multi-step syntheses. It is primarily utilized in the development of active pharmaceutical ingredients (APIs), agrochemicals, and specialty dyes, where its Boc-protected amine group offers strategic advantages in reaction sequences.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, particularly for introducing protected amine functionalities.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides.
• Dye and Pigment Manufacturing: Serves as a precursor for high-performance azo dyes and other nitro-aromatic based colorants.
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and advanced polymers.
• Peptide Chemistry: Useful in solid-phase peptide synthesis (SPPS) for the temporary protection of amine groups.
• Cross-Coupling Reactions: Acts as a substrate in Buchwald-Hartwig amination and other palladium-catalyzed transformations.

Basic Information

Product Name	N,n-Di-Boc-4-Nitroaniline
CAS No.	395639-03-9
Molecular Formula	C₁₆H₂₂N₂O₆
Molecular Weight	338.36 g/mol
Synonyms	Di-tert-butyl 4-nitrobenzene-1,1-diyldicarbamate; 4-Nitro-N,N-bis[(tert-butoxy)carbonyl]aniline; 1,1-Di-Boc-4-nitroaniline; N,N-Bis(tert-butoxycarbonyl)-4-nitroaniline; N,N-Di-Boc-p-nitroaniline; N,N-Di-tert-butoxycarbonyl-4-nitroaniline; 4-Nitro-N,N-di-Boc-aniline; Di-Boc-4-nitroaniline
EINECS	Contact for details

Quality Control

Our N,n-Di-Boc-4-Nitroaniline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using a desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.