Description

2-Propanesulfinamide, n-[2-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Ethylidene]-2-Methyl-, [N(E),S(R)]- is a high-purity, stereochemically defined chiral sulfinamide building block essential for asymmetric synthesis. Its core value lies in its role as a versatile chiral auxiliary and ligand, enabling the stereoselective construction of complex molecules with high enantiomeric purity. This advanced intermediate is critically needed by R&D and process chemistry teams in the pharmaceutical, agrochemical, and fine chemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral building block for the asymmetric synthesis of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and process development.
• Chiral Auxiliary: Used to induce stereoselectivity in a wide range of organic transformations, including nucleophilic additions to imines and carbonyl compounds.
• Ligand Precursor: Serves as a precursor for the synthesis of chiral ligands used in asymmetric catalysis, such as in transition metal-catalyzed reactions.
• Agrochemical Synthesis: Employed in the research and production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Integral to the manufacture of specialty chemicals, flavors, and fragrances where specific stereochemistry is required.
• Academic & Industrial Research: A valuable reagent for methodological development in synthetic organic chemistry and asymmetric synthesis studies.

Basic Information

Product Name	2-Propanesulfinamide, n-[2-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Ethylidene]-2-Methyl-, [N(E),S(R)]-
CAS No.	393536-19-1
Molecular Formula	C12H27NO2SSi
Molecular Weight	277.50 g/mol
Synonyms	(R)-N-((E)-1-((tert-Butyldimethylsilyl)oxy)ethylidene)-2-methylpropane-2-sulfinamide; (R,E)-N-(1-(tert-Butyldimethylsilyloxy)ethylidene)-2-methylpropane-2-sulfinamide; (R)-N-((E)-1-((tert-Butyldimethylsilyl)oxy)ethylidene)-2-methylpropane-2-sulfinamide; TBS-Protected Chiral Sulfinimine; tert-Butyldimethylsilyl (R,E)-N-(1-hydroxyethylidene)-2-methylpropane-2-sulfinamide ether; Chiral N-sulfinyl imine TBS ether; [N(E),S(R)]-2-Propanesulfinamide, N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethylidene]-2-methyl-
EINECS	Contact for details

Quality Control

Our 2-Propanesulfinamide, n-[2-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Ethylidene]-2-Methyl-, [N(E),S(R)]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. Certificates of Analysis (COA) with full characterization data are provided to guarantee traceability, consistency, and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.