Description

tert-Butyl 3-Oxo-1-thia-4,8-diazaspiro[4.5]decane-8-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic scaffold. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily sought by research organizations, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates.
• Protease Inhibitor Synthesis: Used in constructing core structures for inhibitors targeting various protease enzymes.
• Heterocyclic Chemistry: Serves as a versatile spirocyclic template for medicinal chemistry and library synthesis.
• API Process Development: Employed in scaling up and optimizing synthetic routes for potential active pharmaceutical ingredients.
• Chemical Biology Research: Utilized as a molecular probe or scaffold in studying biological pathways and protein interactions.
• Custom Synthesis: A starting material for the contract manufacturing of specialized fine chemicals and bespoke intermediates.

Basic Information

Product Name	tert-Butyl 3-Oxo-1-thia-4,8-diazaspiro[4.5]decane-8-carboxylate
CAS No.	392331-35-0
Molecular Formula	C12H20N2O3S
Molecular Weight	272.36 g/mol
Synonyms	8-Boc-3-oxo-1-thia-4,8-diazaspiro[4.5]decan-4-ium; tert-Butyl 3-oxo-1-thia-4,8-diazaspiro[4.5]decane-8-carboxylate; 1-Thia-4,8-diazaspiro[4.5]decane-8-carboxylic acid, 3-oxo-, 1,1-dimethylethyl ester; 8-(tert-Butoxycarbonyl)-3-oxo-1-thia-4,8-diazaspiro[4.5]decan-4-ium; Spirocyclic thiadiazinone carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Oxo-1-thia-4,8-diazaspiro[4.5]decane-8-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.