Description

3-(2-(Trimethylsilyl)Ethynyl)Phenol is a versatile organosilicon intermediate featuring a phenolic hydroxyl group and a protected terminal alkyne. This unique bifunctional structure makes it a valuable building block for synthesizing complex molecules in advanced material and pharmaceutical research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty polymer industries.

Application

• Pharmaceutical Intermediate: Key synthon for constructing drug candidates, particularly in the development of kinase inhibitors and other targeted therapies via Sonogashira and other cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and production of novel pesticides and herbicides, where the phenol and alkyne functionalities allow for structural diversification.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, resins, and silicon-containing advanced materials.
• Ligand and Catalyst Development: Employed in the synthesis of sophisticated ligands for catalysis and molecular recognition applications.
• Chemical Biology Probes: Useful for creating tagged molecules and bioconjugates for diagnostic and research purposes, leveraging the "click chemistry" compatibility of the alkyne group.
• Organic Electronic Materials: Investigated as a component in the synthesis of organic semiconductors and light-emitting materials due to its conjugated system potential.

Basic Information

Product Name	3-(2-(Trimethylsilyl)Ethynyl)Phenol
CAS No.	388061-72-1
Molecular Formula	C11H14OSi
Molecular Weight	190.31 g/mol
Synonyms	3-[(Trimethylsilyl)ethynyl]phenol; 3-Hydroxyphenyl(trimethylsilyl)acetylene; 3-(Trimethylsilylethynyl)phenol; m-(Trimethylsilylethynyl)phenol; Phenol, 3-[(trimethylsilyl)ethynyl]-; 3-(2-Trimethylsilylethynyl)phenol; TMS-Ethynyl-m-phenol
EINECS	Contact for details

Quality Control

Our 3-(2-(Trimethylsilyl)Ethynyl)Phenol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, confirming compliance with customer specifications and internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.