Description

2-Amino-6-(Trifluoromethyl)Benzoic Acid, Trihydrate is a high-purity, trifluoromethyl-substituted benzoic acid derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both an amino and a carboxylic acid functional group alongside a trifluoromethyl moiety, makes it an invaluable intermediate for creating complex molecules with enhanced properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where the trifluoromethyl group is prized for its ability to improve metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the creation of small molecule drugs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group contributes to improved efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the creation of novel polymers, liquid crystals, and organic electronic materials that require fluorine-containing aromatic units for specific electronic or hydrophobic characteristics.
• Chemical Biology Probes: Utilized as a building block for fluorescent tags, enzyme inhibitors, and other molecular probes in biochemical and diagnostic research.

Basic Information

Product Name	2-Amino-6-(Trifluoromethyl)Benzoic Acid, Trihydrate
CAS No.	387358-50-1
Molecular Formula	C8H6F3NO2 · 3H2O
Molecular Weight	245.15 g/mol (Anhydrous basis)
Synonyms	6-Amino-2-(trifluoromethyl)benzoic acid trihydrate; 2-Amino-α,α,α-trifluoro-o-toluic acid trihydrate; Benzoic acid, 2-amino-6-(trifluoromethyl)-, trihydrate; 2-Carboxy-3-aminobenzotrifluoride trihydrate; 2-Amino-6-trifluoromethylbenzoic acid trihydrate; 6-Trifluoromethylanthranilic acid trihydrate; ATFBA trihydrate
EINECS	Contact for details

Quality Control

Our 2-Amino-6-(Trifluoromethyl)Benzoic Acid, Trihydrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and commercial synthesis. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed to prevent absorption of atmospheric moisture, which may affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	19.0% - 22.0% (Theoretical for Trihydrate: ~18.1%)
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.