Description

trans-4-Methyltetrahydrofuran-3-Ol CAS NO 387357-58-6 is a high-purity chiral building block and intermediate of significant interest in advanced organic synthesis. Its value lies in its unique stereochemistry and functional group arrangement, which makes it a versatile precursor for complex molecules. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for developing active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Used in the production of advanced, stereospecific pesticides and herbicides where biological activity is highly dependent on molecular configuration.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to induce high enantioselectivity.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances that require specific stereochemical purity.
• Academic and R&D: A valuable compound for methodological research in organic chemistry, exploring new synthetic routes and reaction mechanisms.

Basic Information

Product Name	trans-4-Methyltetrahydrofuran-3-Ol
CAS No.	387357-58-6
Molecular Formula	C5H10O2
Molecular Weight	102.13 g/mol
Synonyms	(3R,4S)-4-Methyltetrahydrofuran-3-ol; (3S,4R)-4-Methyltetrahydrofuran-3-ol; trans-4-Methyl-3-hydroxytetrahydrofuran; 3-Tetrahydrofuranol, 4-methyl-, trans-; 4-Methyltetrahydro-3-furanol; THF derivative, chiral alcohol; Chiral furan alcohol intermediate
EINECS	Contact for details

Quality Control

Our trans-4-Methyltetrahydrofuran-3-Ol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC and GC, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) with detailed specifications for identity, assay, and impurity profile are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C for long-term stability. This compound is hygroscopic and easily oxidized; therefore, containers must be kept sealed and handled under anhydrous conditions to prevent degradation and maintain purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.