Description

6-(Trifluoromethyl)Nicotinohydrazide is a high-value trifluoromethylated pyridine derivative, serving as a critical building block in modern synthetic chemistry. Its unique structure, combining a nicotinohydrazide core with a trifluoromethyl group, offers exceptional versatility for constructing complex molecules with tailored properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients with improved metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly for antiviral, anticancer, and central nervous system (CNS) targeted therapies.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Ligand & Catalyst Development: Serves as a versatile scaffold for creating specialized ligands in coordination chemistry and catalysis.
• Material Science Research: Employed in the synthesis of functional organic materials, such as liquid crystals or organic semiconductors.
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	6-(Trifluoromethyl)Nicotinohydrazide
CAS No.	386715-32-8
Molecular Formula	C7H6F3N3O
Molecular Weight	205.14 g/mol
Synonyms	6-(Trifluoromethyl)pyridine-3-carbohydrazide; 3-Pyridinecarboxylic acid, 6-(trifluoromethyl)-, hydrazide; Nicotinic acid, 6-(trifluoromethyl)-, hydrazide; 6-Trifluoromethylnicotinohydrazide; 6-Trifluoromethyl-3-pyridinecarbohydrazide; 3-Hydrazinylcarbonyl-6-(trifluoromethyl)pyridine
EINECS	Contact for details

Quality Control

Every batch of 6-(Trifluoromethyl)Nicotinohydrazide is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay (HPLC), related substances, and residual solvents. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.