Description

2-Phenyl-1,2,3,4-tetrahydroacridine-9-carboxylic acid is a high-purity, advanced pharmaceutical intermediate of significant interest in modern medicinal chemistry. This compound serves as a critical building block for the synthesis of novel therapeutic agents, particularly those targeting neurological pathways. It is essential for research and development laboratories, pharmaceutical manufacturers, and fine chemical suppliers focused on creating next-generation drug candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of acetylcholinesterase (AChE) inhibitors and other central nervous system (CNS) active compounds.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new drug discovery programs.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core scaffold for the development of potential APIs targeting Alzheimer's disease and related cognitive disorders.
• Fine Chemical Synthesis: Employed in multi-step organic syntheses to construct complex heterocyclic systems with biological activity.
• Biochemical Tool Compound: Utilized in vitro and in vivo studies to investigate cholinergic system modulation and enzyme inhibition mechanisms.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	2-Phenyl-1,2,3,4-tetrahydroacridine-9-carboxylic Acid
CAS No.	379238-97-8
Molecular Formula	C20H17NO2
Molecular Weight	303.36 g/mol
Synonyms	9H-Pyrido[2,3-b]quinoline-9-carboxylic acid, 1,2,3,4-tetrahydro-2-phenyl-; 2-Phenyl-1,2,3,4-tetrahydroacridine-9-carboxylic acid; 9-Carboxy-2-phenyl-1,2,3,4-tetrahydroacridine; Tetrahydroacridine-9-carboxylic acid derivative; PTAC; THA-9-COOH; Acridine-9-carboxylic acid, 1,2,3,4-tetrahydro-2-phenyl-
EINECS	Contact for details

Quality Control

Our 2-Phenyl-1,2,3,4-tetrahydroacridine-9-carboxylic acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is stable under these conditions but should be handled in accordance with good laboratory practices for chemicals soluble in strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.