Description

4(3H)-Quinazolinone, 7-Fluoro-5-[(Tetrahydro-2H-Pyran-4-Yl)Oxy]- is a high-purity, advanced pharmaceutical intermediate characterized by its unique quinazolinone core substituted with fluorine and a tetrahydropyranyloxy group. This compound is of significant value for medicinal chemistry research and development, offering a versatile scaffold for the synthesis of novel bioactive molecules. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new therapeutic agents, particularly in oncology and CNS drug discovery.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Kinase Inhibitor Development: The quinazolinone structure is prevalent in compounds designed to inhibit specific kinases, relevant for cancer and inflammatory diseases.
• Chemical Biology Probes: Serves as a starting material for creating molecular probes to study biological processes and identify new drug targets.
• Custom Synthesis: Utilized by contract research and manufacturing organizations (CROs/CMOs) for the custom synthesis of complex molecules for clients.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	4(3H)-Quinazolinone, 7-Fluoro-5-[(Tetrahydro-2H-Pyran-4-Yl)Oxy]-
CAS No.	379228-59-8
Molecular Formula	C₁₃H₁₃FN₂O₃
Molecular Weight	264.25 g/mol
Synonyms	7-Fluoro-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4(3H)-quinazolinone; 7-Fluoro-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4(3H)-one; 5-[(Oxan-4-yl)oxy]-7-fluoro-3H-quinazolin-4-one; 379228-59-8; 7-Fluoro-5-(tetrahydropyran-4-yloxy)-4(3H)-quinazolinone; 4(3H)-Quinazolinone, 7-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)-; 7-Fluoro-5-(tetrahydro-2H-pyran-4-yloxy)-4(3H)-quinazolinone
EINECS	Contact for details

Quality Control

Our production of 4(3H)-Quinazolinone, 7-Fluoro-5-[(Tetrahydro-2H-Pyran-4-Yl)Oxy]- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All materials undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development and commercial projects with material produced under a cGMP-compliant quality system where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to protect the compound from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.