Description

1-(Bromomethyl)-4-Iodo-2-Nitrobenzene is a versatile halogenated aromatic building block of significant interest in advanced organic synthesis. Its molecular structure, featuring bromomethyl, iodo, and nitro functional groups, makes it a key precursor for constructing complex molecules through sequential cross-coupling and substitution reactions. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring halogenated aromatic scaffolds.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the nitro and halogen substituents are essential for bioactivity.
• Material Science Research: Acts as a monomer or functionalization agent in the creation of specialty polymers and advanced organic materials.
• Ligand and Catalyst Development: Employed in the preparation of complex ligands for transition metal catalysis and organocatalysts.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags for studying biological systems due to its reactive halogen handles.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions, leveraging the iodo and bromomethyl groups.

Basic Information

Product Name	1-(Bromomethyl)-4-Iodo-2-Nitrobenzene
CAS No.	375792-98-6
Molecular Formula	C7H5BrINO2
Molecular Weight	341.93 g/mol
Synonyms	4-Iodo-2-nitrobenzyl bromide; 2-Nitro-4-iodobenzyl bromide; (4-Iodo-2-nitrophenyl)methyl bromide; 1-Bromomethyl-4-iodo-2-nitrobenzene; Benzene, 1-(bromomethyl)-4-iodo-2-nitro-; α-Bromo-4-iodo-2-nitrotoluene
EINECS	Contact for details

Quality Control

Our 1-(Bromomethyl)-4-Iodo-2-Nitrobenzene is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles. Our quality system is designed to meet the stringent requirements of process chemistry and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.