Description

3,3-Difluoro-4-Methylpiperidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluorinated piperidine scaffold. This compound matters for its critical role in modern medicinal chemistry, where the introduction of fluorine atoms is a key strategy to modulate the bioavailability, metabolic stability, and binding affinity of drug candidates. Pharmaceutical R&D and fine chemical synthesis teams need this building block for the development of novel therapeutics, particularly in central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for CNS-targeting drugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to improve drug-like properties through fluorination.
• Protease Inhibitor Synthesis: Serves as a core structural motif in the development of protease inhibitors for various therapeutic areas.
• Ligand and Receptor Modulator Development: Employed in creating potent and selective ligands for G-protein-coupled receptors (GPCRs) and other biological targets.
• Agrochemical Research: Potential intermediate in the development of advanced crop protection agents with enhanced efficacy.
• Fluorinated Compound Library Synthesis: A valuable reagent for constructing diverse fluorinated compound libraries for high-throughput screening.

Basic Information

Product Name	3,3-Difluoro-4-Methylpiperidine Hydrochloride
CAS No.	374794-78-2
Molecular Formula	C6H12ClF2N
Molecular Weight	171.62 g/mol
Synonyms	4-Methyl-3,3-difluoropiperidine hydrochloride; 3,3-Difluoro-4-methylpiperidine HCl; 3,3-Difluoro-4-methylpiperidine, hydrochloride; Piperidine, 3,3-difluoro-4-methyl-, hydrochloride; 4-Methyl-3,3-difluoropiperidine HCl salt
EINECS	Contact for details

Quality Control

Our 3,3-Difluoro-4-Methylpiperidine Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A detailed Certificate of Analysis (COA) is supplied with each batch, documenting identity, purity, and impurity profiles to support your regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.