Description

1-Bromo-2,3-difluoro-5-nitrobenzene is a high-purity, multi-functional halogenated nitrobenzene derivative, serving as a critical building block in advanced organic synthesis. Its unique combination of bromine, fluorine, and nitro substituents makes it a versatile intermediate for constructing complex molecular architectures with tailored electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules requiring fluorinated aromatic cores to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, where the difluoro and nitro groups contribute to biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated aromatic components in electronic materials, enhancing charge transport and thermal stability.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form complex biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and fluorine groups allow for selective substitution reactions, enabling precise functionalization of the benzene ring.
• Research & Development: A valuable reagent for academic and industrial R&D in medicinal chemistry and material science for exploring new chemical entities.

Basic Information

Product Name	1-Bromo-2,3-difluoro-5-nitrobenzene
CAS No.	374633-24-6
Molecular Formula	C6H2BrF2NO2
Molecular Weight	237.99 g/mol
Synonyms	2-Bromo-1,3-difluoro-5-nitrobenzene; 3-Bromo-2,6-difluoronitrobenzene; Benzene, 1-bromo-2,3-difluoro-5-nitro-; 5-Nitro-1-bromo-2,3-difluorobenzene; 2,3-Difluoro-5-nitro-1-bromobenzene; 1-Bromo-2,3-difluoro-5-nitro-benzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2,3-difluoro-5-nitrobenzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques, including HPLC, GC, and NMR, to verify identity and quantify impurities. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in light-resistant packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.