Description

Propanamide, 2-Amino-3-Hydroxy-n-(Phenylmethyl)- CAS NO 374088-96-7 is a specialized amino acid derivative with a benzyl-protected amine group, serving as a critical chiral building block in advanced organic synthesis. Its molecular structure makes it a valuable precursor for the development of pharmaceuticals and bioactive compounds, particularly in the synthesis of complex peptides and enzyme inhibitors. This high-purity intermediate is essential for research and production in pharmaceutical development, agrochemical research, and fine chemical manufacturing where precise stereochemistry is required.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in neurologic and metabolic drug candidates.
• Peptide Chemistry: Used as a protected amino acid analog in solid-phase peptide synthesis (SPPS) and the construction of peptide mimetics.
• Agrochemical Research: Serves as a building block for novel herbicides, fungicides, and plant growth regulators requiring specific stereochemical configurations.
• Bioconjugation & Probe Development: Utilized in the design of chemical probes, affinity labels, and linker molecules for biochemical and diagnostic applications.
• Asymmetric Catalysis Ligand Synthesis: A precursor for chiral ligands and organocatalysts used in enantioselective transformations.
• Fine Chemical & Specialty Chemical Production: Intermediate for manufacturing high-value, complex organic molecules with specific optical activity.

Basic Information

Item	Detail
Product Name	Propanamide, 2-Amino-3-Hydroxy-n-(Phenylmethyl)-
CAS No.	374088-96-7
Molecular Formula	C₁₀H₁₄N₂O₂
Molecular Weight	194.23 g/mol
Synonyms	2-Amino-3-hydroxy-N-benzylpropanamide; N-Benzyl-2-amino-3-hydroxypropanamide; 3-Hydroxy-2-aminopropanamide, N-benzyl-; L-Threoninamide, N-benzyl- (related derivative); (2-Amino-3-hydroxy-propyl)-benzyl-amine amide; Amino-hydroxy benzyl propanamide; BAPA (abbreviation); HAPA-Benzyl
EINECS	Contact for details

Quality Control

Our Propanamide, 2-Amino-3-Hydroxy-n-(Phenylmethyl)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including chiral purity assessment by HPLC, identity confirmation by IR and NMR, and precise quantification of residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.