Description

Dichloro[1,3-Bis(2,6-Isopropylphenyl)-2-Imidazolidinylidene](Benzylidene)(Tricyclohexylphosphine)Ruthenium(II) is a highly specialized, second-generation Grubbs-Hoveyda type olefin metathesis catalyst. This compound is valued for its exceptional thermal stability and functional group tolerance, enabling complex synthetic transformations under mild conditions. It is a critical reagent for researchers and process chemists in pharmaceutical development, advanced materials science, and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate Synthesis: Enabling key ring-closing metathesis (RCM), cross metathesis (CM), and ring-opening metathesis polymerization (ROMP) steps in the production of active pharmaceutical ingredients (APIs).
• Advanced Polymer & Material Science: Catalyst for the ROMP of norbornene and other strained cyclic olefins to create specialty polymers with precise architectures for coatings, composites, and elastomers.
• Agrochemical Research: Facilitating the synthesis of novel, complex molecular structures for crop protection agents and plant growth regulators.
• Fine Chemical & Fragrance Manufacturing: Used in the efficient construction of medium-to-large ring systems and complex olefinic structures that are difficult to access via traditional methods.
• Academic & Industrial R&D: A staple catalyst in discovery chemistry for exploring new synthetic pathways and developing novel methodologies in organic synthesis.

Basic Information

Product Name	Dichloro[1,3-Bis(2,6-Isopropylphenyl)-2-Imidazolidinylidene](Benzylidene)(Tricyclohexylphosphine)Ruthenium(II)
CAS No.	373640-75-6
Molecular Formula	C₄₆H₆₆Cl₂N₂PRu
Molecular Weight	848.96 g/mol
Synonyms	Grubbs-Hoveyda Catalyst 2nd Generation; Hoveyda-Grubbs Catalyst II; Dichloro(o-isopropoxyphenylmethylene)(tricyclohexylphosphine)ruthenium(II) with NHC ligand; (1,3-Bis(2,6-diisopropylphenyl)-2-imidazolidinylidene)dichloro(o-isopropoxyphenylmethylene)ruthenium(II); RuCl₂(IMesH₂)(CH-2-O-iPr-C₆H₄)(PCy₃); HG-II Catalyst; CAS 373640-75-6
EINECS	Contact for details

Quality Control

Every batch of our Grubbs-Hoveyda 2nd Generation Catalyst is manufactured and tested under strict quality protocols to ensure high catalytic activity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and performance-relevant parameters. Our quality system supports compliance with cGMP standards for pharmaceutical applications and meets the rigorous demands of research and industrial-scale synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a freezer. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures will degrade catalytic activity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Purple to brown crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Solubility	Soluble in common organic solvents (DCM, toluene, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.