Description

3-n-Fmoc-Amino-3-(2-T-Butoxyphenyl)Propionic Acid is a sophisticated, non-natural amino acid derivative designed for advanced peptide synthesis and medicinal chemistry research. This compound is a critical building block for the solid-phase synthesis of complex peptides, enabling the precise introduction of side-chain modifications. It is primarily utilized by pharmaceutical R&D teams, biotech companies, and CROs (Contract Research Organizations) developing novel therapeutic peptides and peptidomimetics. Its protected functional groups ensure compatibility with standard Fmoc-based peptide coupling strategies.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the Fmoc-strategy, facilitating the incorporation of a modified phenylalanine residue into peptide chains.
• Peptidomimetic Drug Discovery: Used to synthesize peptide analogs with enhanced stability, bioavailability, and target specificity for therapeutic applications.
• Chemical Biology Probes: Enables the creation of labeled or tagged peptides for studying protein-protein interactions and cellular pathways.
• API (Active Pharmaceutical Ingredient) Development: Serves as an intermediate in the research and development stages of peptide-based active pharmaceutical ingredients.
• Combinatorial Chemistry Libraries: Used to generate diverse libraries of peptide-like compounds for high-throughput screening against biological targets.

Basic Information

Item	Details
Product Name	3-n-Fmoc-Amino-3-(2-T-Butoxyphenyl)Propionic Acid
CAS No.	372144-18-8
Molecular Formula	C28H29NO5
Molecular Weight	459.54 g/mol
Synonyms	Fmoc-3-amino-3-(2-tert-butoxyphenyl)propanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-3-(2-tert-butoxyphenyl)propanoic acid; 3-(2-(tert-Butoxy)phenyl)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)propanoic acid; Fmoc-Amp(2-tBuO)-OH; Fmoc-3-Amino-3-(2-tert-butoxyphenyl)propionic Acid; 3-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-[2-(tert-butoxy)phenyl]propanoic acid
EINECS	Contact for details

Quality Control

Our 3-n-Fmoc-Amino-3-(2-T-Butoxyphenyl)Propionic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral purity analysis where applicable. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or CoA. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.