Description

3-n-Fmoc-Amino-3-(3-T-Butoxyphenyl)Propionic Acid is a sophisticated, non-natural amino acid derivative designed for advanced peptide synthesis and medicinal chemistry research. This compound is a critical building block for the solid-phase synthesis of complex peptides, enabling the precise incorporation of a side-chain protected tyrosine analog. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on developing novel peptide-based therapeutics, diagnostics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the automated synthesis of custom peptides containing modified tyrosine residues.
• Medicinal Chemistry & Drug Discovery: Used in the research and development of peptide drugs, hormone analogs, and targeted biologics where structural modification is required for stability or activity.
• Bioconjugation & Probe Development: Serves as a precursor for creating fluorescently labeled peptides, affinity tags, or peptide-drug conjugates for diagnostic and therapeutic applications.
• Chemical Biology Research: Employed in studying protein-protein interactions, enzyme mechanisms, and receptor binding by incorporating this non-standard amino acid into peptide sequences.
• Process Development & Scale-Up: Supports the transition from laboratory-scale research to pilot and commercial manufacturing of peptide active pharmaceutical ingredients (APIs).

Basic Information

Product Name	3-n-Fmoc-Amino-3-(3-T-Butoxyphenyl)Propionic Acid
CAS No.	372144-16-6
Molecular Formula	C₂₈H₂₉NO₅
Molecular Weight	459.54 g/mol
Synonyms	Fmoc-3-(3-(tert-Butoxy)phenyl)-β-homoalanine; 3-(3-(tert-Butoxyphenyl))-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)propanoic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(3-tert-butoxyphenyl)-β-alanine; Fmoc-3-(3-t-Butoxyphenyl)-β-homoalanine; Fmoc-3-(3-tert-Butoxyphenyl)-β-Ala-OH; 3-(3-tert-Butoxyphenyl)-3-(Fmoc-amino)propionic Acid; N-Fmoc-3-(3-tert-butoxyphenyl)-β-alanine
EINECS	Contact for details

Quality Control

Every batch of 3-n-Fmoc-Amino-3-(3-T-Butoxyphenyl)Propionic Acid is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are suitable for demanding research and development applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with our rigorous specifications for HPLC purity, chiral purity, and residual solvent content.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.