Description

cis-5-Benzyl-2-Boc-Hexahydropyrrolo[3,4-C]Pyrrole is a high-purity, advanced pharmaceutical intermediate featuring a protected hexahydropyrrolopyrrole scaffold. This compound is a critical building block in modern medicinal chemistry, valued for its role in constructing complex nitrogen-containing heterocycles essential for drug discovery. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents, particularly within central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of potent, biologically active molecules targeting various disease pathways.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing fused bicyclic amine structures in lead optimization and structure-activity relationship (SAR) studies.
• API Development: Used in the research and development stages of Active Pharmaceutical Ingredient (API) manufacturing for new chemical entities.
• CNS Drug Candidates: Particularly relevant in the synthesis of compounds designed to cross the blood-brain barrier for neurological and psychiatric applications.
• Oncology Therapeutics: Employed in the creation of kinase inhibitors and other targeted cancer therapies that require sophisticated heterocyclic cores.
• Chemical Biology Probes: Utilized to develop tool compounds for probing biological function and validating novel drug targets.

Basic Information

Product Name	cis-5-Benzyl-2-Boc-Hexahydropyrrolo[3,4-C]Pyrrole
CAS No.	370879-56-4
Molecular Formula	C19H26N2O2
Molecular Weight	314.43 g/mol
Synonyms	5-Benzyl-2-[(tert-butoxy)carbonyl]-2,5-diazabicyclo[2.2.1]heptane; 2-Boc-5-benzyl-2,5-diazabicyclo[2.2.1]heptane; tert-Butyl 5-benzyl-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate; 5-Benzyl-2-(tert-butoxycarbonyl)-2,5-diazabicyclo[2.2.1]heptane; (1R,4R)-5-Benzyl-2-(tert-butoxycarbonyl)-2,5-diazabicyclo[2.2.1]heptane (cis-isomer); BOC-Protected 5-Benzyl-2,5-diazabicyclo[2.2.1]heptane; Hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylic acid, 5-(phenylmethyl)-, 1,1-dimethylethyl ester, (3aR,6aR)-rel-
EINECS	Contact for details

Quality Control

Our cis-5-Benzyl-2-Boc-Hexahydropyrrolo[3,4-C]Pyrrole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines for pharmaceutical intermediates, ensuring traceability and reliability for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.