Description

3-(((4-Chloro-2,5-Dimethoxyphenyl)Amino)Methylene)-1,5-Dioxaspiro[5.5]Undecane-2,4-Dione is a high-purity, advanced pharmaceutical intermediate with a complex spirocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in research targeting central nervous system and metabolic disorders. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in innovative drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of proprietary drug candidates, especially those with complex heterocyclic architectures.
• Drug Discovery Research: Serves as a versatile scaffold for medicinal chemists to explore structure-activity relationships (SAR) in new therapeutic programs.
• Chemical Reference Standard: Used as a high-purity standard for analytical method development, validation, and quality control in API manufacturing.
• Process Chemistry Development: Employed in route scouting and optimization studies for the scalable production of target molecules.
• Academic & Institutional Research: Utilized in universities and research institutes for studies in organic synthesis methodology and bioorganic chemistry.

Basic Information

Product Name	3-(((4-Chloro-2,5-Dimethoxyphenyl)Amino)Methylene)-1,5-Dioxaspiro[5.5]Undecane-2,4-Dione
CAS No.	370853-94-4
Molecular Formula	C20H22ClNO6
Molecular Weight	407.85 g/mol
Synonyms	1,5-Dioxaspiro[5.5]undecane-2,4-dione, 3-[[(4-chloro-2,5-dimethoxyphenyl)amino]methylene]-; 3-(((4-Chloro-2,5-dimethoxyphenyl)amino)methylene)-1,5-dioxaspiro[5.5]undecane-2,4-dione; 3-[(4-Chloro-2,5-dimethoxyanilino)methylidene]-1,5-dioxaspiro[5.5]undecane-2,4-dione; Spiro[1,3-dioxane-5,2'-tricyclo[3.3.1.1³,⁷]decane]-2,4-dione derivative; (4-Chloro-2,5-dimethoxyphenyl)aminomethylene Meldrum's acid derivative; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of this intermediate is produced under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by HPLC, NMR, and mass spectrometry. Our quality commitment aligns with cGMP principles for pharmaceutical starting materials, ensuring traceability, consistency, and reliability for critical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture ingress.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.