Description

1-[(3,4-Dimethoxyphenyl)Sulfonyl]Proline is a specialized proline derivative featuring a sulfonyl linker and dimethoxyphenyl group, offering unique chemical functionality for advanced synthesis. This compound matters as a sophisticated chiral building block and intermediate, enabling the construction of complex molecules with precise stereochemistry. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new active pharmaceutical ingredients (APIs), peptidomimetics, and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Peptidomimetic Chemistry: Serves as a constrained proline analog for designing and synthesizing peptide mimics with enhanced metabolic stability and bioavailability.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or ligand in catalytic asymmetric reactions to induce stereoselectivity.
• Protease Inhibitor Development: Acts as a core scaffold or intermediate in the design of inhibitors for various protease enzymes.
• Chemical Biology Research: Employed in probe and tool compound synthesis for studying biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	1-[(3,4-Dimethoxyphenyl)Sulfonyl]Proline
CAS No.	367928-20-9
Molecular Formula	C₁₃H₁₇NO₆S
Molecular Weight	315.34 g/mol
Synonyms	1-(3,4-Dimethoxybenzenesulfonyl)proline; L-Proline, 1-[(3,4-dimethoxyphenyl)sulfonyl]-; (S)-1-((3,4-Dimethoxyphenyl)sulfonyl)pyrrolidine-2-carboxylic acid; 367928-20-9; Proline sulfonamide derivative; Dimethoxyphenylsulfonyl proline
EINECS	Contact for details

Quality Control

Our 1-[(3,4-Dimethoxyphenyl)Sulfonyl]Proline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and advanced synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.