Description

H-Dap(Fmoc)-Oh·Hcl CAS NO 366009-04-3 is a protected amino acid derivative, specifically the hydrochloride salt of Fmoc-Dap-OH, which serves as a critical building block in solid-phase peptide synthesis (SPPS). This compound is essential for the controlled introduction of the diaminopropionic acid (Dap) residue, enabling the creation of complex peptides with specific structural and functional properties. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of custom peptide sequences.
• Pharmaceutical Research: Building block for the development of novel peptide-based drugs, including antimicrobial peptides and hormone analogs.
• Bioconjugation: Used to introduce reactive amine handles or specific spacers into peptides for coupling with other molecules like dyes, polymers, or proteins.
• Chemical Biology Probes: Synthesis of labeled or modified peptides used to study protein-protein interactions and enzyme activity.
• Material Science: Incorporation into peptide-based biomaterials and hydrogels for tissue engineering and drug delivery systems.
• Antibody-Drug Conjugate (ADC) Development: Potential use in constructing specialized linkers or payload-attachment sites in ADC platforms.

Basic Information

Product Name	H-Dap(Fmoc)-Oh·Hcl
CAS No.	366009-04-3
Molecular Formula	C19H20N2O5 · HCl
Molecular Weight	392.83 g/mol (Free base: 356.38)
Synonyms	Fmoc-Dap-OH·HCl; Fmoc-L-2,3-diaminopropionic acid hydrochloride; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2,3-diaminopropanoic acid hydrochloride; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-aminopropanoic acid hydrochloride; Fmoc-L-Dap-OH·HCl; Nα-Fmoc-L-2,3-diaminopropionic acid HCl; Fmoc-2,3-diaminopropionic acid hydrochloride; H-Dap(Fmoc)-OH hydrochloride
EINECS	Contact for details

Quality Control

Our H-Dap(Fmoc)-Oh·Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee batch-to-batch consistency and reproducible performance in your applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.