Description

(2S,4R)-4-Methylpyrrolidine-2-Carboxylic Acid Hydrochloride is a high-purity, non-natural amino acid derivative and a key chiral building block in advanced organic synthesis. Its defined stereochemistry at the 2 and 4 positions makes it a critical intermediate for constructing complex molecules with precise three-dimensional architecture. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients, peptide mimetics, and chiral catalysts.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in protease inhibitors, neurological agents, and other therapeutic compounds requiring specific stereochemistry.
• Peptidomimetics & Constrained Peptides: Used to introduce conformational constraints into peptide backbones, enhancing metabolic stability and biological activity for drug discovery programs.
• Asymmetric Catalysis: Serves as a precursor for chiral ligands and organocatalysts used in enantioselective synthesis to produce optically pure compounds.
• Agrochemical Research: Employed in the development of novel, stereospecific herbicides, fungicides, and plant growth regulators.
• Chemical Biology & Proteomics: Utilized as a building block for activity-based probes and other tools to study enzyme function and protein-protein interactions.
• Academic & Process R&D: A valuable reagent for methodological development in organic chemistry and for scaling up synthetic routes in process chemistry.

Basic Information

Product Name	(2S,4R)-4-Methylpyrrolidine-2-Carboxylic Acid Hydrochloride
CAS No.	365280-18-8
Molecular Formula	C7H14ClNO2
Molecular Weight	179.65 g/mol
Synonyms	(2S,4R)-4-Methyl-2-pyrrolidinecarboxylic Acid Hydrochloride; (2S,4R)-4-Methylproline Hydrochloride; cis-4-Methyl-D-proline Hydrochloride; (2S,4R)-HMP.HCl; 4-Methyl-D-proline Hydrochloride (cis); L-cis-4-Methylproline Hydrochloride; 4-Methyl-(2S,4R)-proline HCl; 365280-18-8
EINECS	Contact for details

Quality Control

Our (2S,4R)-4-Methylpyrrolidine-2-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.