Description

Dichloro[(S)-(+)-4,12-Bis(Di(3,5-Xylyl)Phosphino)-[2.2]-Paracyclophane][(1R,2R)-(+)-1,2-Diphenylethylenediamine]Ruthenium(II), Min. 95% is a high-purity, chiral ruthenium complex designed for advanced asymmetric catalysis. This compound is a highly effective and selective catalyst for hydrogenation and other enantioselective transformations, enabling the production of single-isomer intermediates critical for pharmaceutical and fine chemical synthesis. It is an essential tool for R&D and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop efficient and sustainable synthetic routes.

Application

• Asymmetric Hydrogenation Catalyst: For the enantioselective reduction of ketones, imines, and olefins to produce chiral alcohols, amines, and other building blocks.
• Pharmaceutical Intermediate Synthesis: Production of single-enantiomer active pharmaceutical ingredients (APIs) for drugs targeting CNS disorders, cardiovascular diseases, and infectious diseases.
• Agrochemical Manufacturing: Synthesis of chiral herbicides, fungicides, and plant growth regulators with enhanced efficacy and environmental profile.
• Fine Chemical Production: Enantioselective synthesis of flavors, fragrances, and advanced materials.
• Academic & Industrial R&D: A benchmark catalyst for developing new asymmetric synthetic methodologies and process optimization.
• Chiral Ligand Evaluation: Serves as a pre-formed complex for studying the efficacy of the Josiphos-type ligand system in various metal-catalyzed reactions.

Basic Information

Item	Detail
Product Name	Dichloro[(S)-(+)-4,12-Bis(Di(3,5-Xylyl)Phosphino)-[2.2]-Paracyclophane][(1R,2R)-(+)-1,2-Diphenylethylenediamine]Ruthenium(II), Min. 95%
CAS No.	364795-64-2
Molecular Formula	C64H66Cl2N2P2Ru
Molecular Weight	1088.06 g/mol
Synonyms	Ru-Josiphos-(R,R)-DACH Catalyst; (R,R)-DACH-Ru-Josiphos Dichloride; Dichloro[(S)-4,12-bis[di(3,5-dimethylphenyl)phosphino][2.2]paracyclophane][(1R,2R)-1,2-diphenylethylenediamine]ruthenium; Ruthenium(II) (R,R)-DACH Josiphos complex; [RuCl2((R,R)-DACH)((S)-Josiphos)]; Asymmetric Hydrogenation Catalyst 364795-64-2; (R,R)-DACH-Ru-Josiphos
EINECS	Contact for details

Quality Control

Every batch of our high-purity ruthenium catalyst is manufactured and tested under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, chiral integrity, and metal content to ensure compliance with cGMP and ISO 9001 standards for pharmaceutical and fine chemical applications. Our quality protocols are designed to guarantee batch-to-batch consistency and optimal catalytic performance.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a dry, cool place. This compound is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or ambient light may degrade catalytic activity.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	Min. 95.0%
Chiral Purity (HPLC)	Min. 99.0% ee
Ruthenium Content	9.3 - 9.7%
Solubility	Soluble in dichloromethane, toluene; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.