Description

4-Chloro-7-Iodo-Quinoline-3-Carbonitrile is a high-purity, multi-functional halogenated quinoline derivative, serving as a critical advanced intermediate in modern organic synthesis. Its unique molecular architecture, featuring both chloro and iodo substituents on the quinoline core, makes it an exceptionally versatile building block for constructing complex heterocyclic systems. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for the development of novel active compounds and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly for kinase inhibitors, antimicrobial agents, and other biologically active quinoline-based molecules.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides, leveraging its halogenated structure for bioactivity.
• Material Science: Serves as a building block for organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) due to its rigid, planar structure and halogen atoms for further functionalization.
• Chemical Synthesis: Utilized in cross-coupling reactions (e.g., Suzuki, Sonogashira) where the iodo substituent acts as an excellent leaving group, enabling precise molecular construction.
• Dye and Pigment Intermediate: Acts as a precursor for the synthesis of specialized quinoline-based dyes and fluorescent markers.
• Academic & R&D: A valuable reagent for methodological studies in organic chemistry and for exploring new reaction pathways in heterocyclic chemistry.

Basic Information

Product Name	4-Chloro-7-Iodo-Quinoline-3-Carbonitrile
CAS No.	364793-64-6
Molecular Formula	C10H4ClIN2
Molecular Weight	314.51 g/mol
Synonyms	4-Chloro-7-iodoquinoline-3-carbonitrile; 3-Cyano-4-chloro-7-iodoquinoline; 7-Iodo-4-chloroquinoline-3-carbonitrile; Quinoline-3-carbonitrile, 4-chloro-7-iodo-; 364793-64-6; 4-Chloro-7-iodo-3-quinolinecarbonitrile
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-7-Iodo-Quinoline-3-Carbonitrile is manufactured and tested under a strict quality management system. We guarantee high chemical purity and consistency to meet the rigorous demands of research and process chemistry. Comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, is performed. A detailed Certificate of Analysis (COA) specifying identity, purity, and impurity profiles is provided with each shipment to ensure full traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from incompatible materials. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC/IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.