Description

6-Amino-4-(3-Chloro-4-Fluorophenylamino)-7-Ethoxyquinoline-3-Carbonitrile is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is a critical building block in the synthesis of targeted kinase inhibitors, offering significant value in modern drug discovery and development. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in producing innovative active pharmaceutical ingredients (APIs) for oncology and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule kinase inhibitors for targeted cancer therapies.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core scaffold in multi-step synthetic routes for producing investigational new drugs.
• Biochemical Research: Employed as a tool compound or reference standard in biochemical assays to study specific kinase pathways and mechanisms of action.
• Fine Chemical Manufacturing: Supplied to contract development and manufacturing organizations (CDMOs) for cGMP-scale production of clinical trial materials.

Basic Information

Item	Detail
Product Name	6-Amino-4-(3-Chloro-4-Fluorophenylamino)-7-Ethoxyquinoline-3-Carbonitrile
CAS No.	361162-95-0
Molecular Formula	C18H15ClFN5O
Molecular Weight	371.80 g/mol
Synonyms	6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-ethoxyquinoline-3-carbonitrile; 7-Ethoxy-6-amino-4-(3-chloro-4-fluoroanilino)quinoline-3-carbonitrile; BIBW 2992 Intermediate; Afatinib Intermediate; Afatinib Impurity; Tovok Intermediate; Giotrif Intermediate; Gilotrif Intermediate
EINECS	Contact for details

Quality Control

Our production of 6-Amino-4-(3-Chloro-4-Fluorophenylamino)-7-Ethoxyquinoline-3-Carbonitrile adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with customer specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.