Description

n-Biotinyl-3,6,9-Trioxaundecane-1,11-Diamine is a specialized biotin derivative featuring a hydrophilic polyethylene glycol (PEG) spacer arm. This molecular design is critical for enhancing solubility and reducing steric hindrance, making it an essential intermediate for advanced bioconjugation and labeling strategies. It is primarily utilized by researchers and manufacturers in the pharmaceutical, diagnostic, and life science sectors for developing targeted therapeutics, diagnostic probes, and affinity-based purification systems.

Application

• Bioconjugation Reagent: Used for site-specific labeling of antibodies, proteins, peptides, and other biomolecules with biotin.
• Diagnostic Assay Development: A key component in the synthesis of probes for ELISA, lateral flow assays, and other immunoassay platforms.
• Affinity Chromatography Ligand: Immobilized onto solid supports to create resins for the purification of streptavidin/avidin-tagged proteins.
• Drug Delivery Systems: Serves as a linker in the design of biotinylated drug conjugates and targeted nanoparticle formulations.
• Cell Surface Engineering: Facilitates the biotinylation of cell membranes for studying receptor interactions and cell sorting.
• Molecular Biology: Employed in the preparation of biotin-labeled nucleotides for hybridization and sequencing applications.

Basic Information

Product Name	n-Biotinyl-3,6,9-Trioxaundecane-1,11-Diamine
CAS No.	359860-27-8
Molecular Formula	C21H40N4O5S
Molecular Weight	460.63 g/mol
Synonyms	Biotin-PEG3-amine; Biotin-PEG3-NH2; Biotinamido-PEG3-amine; 5-[(3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]pentanamide; Biotin-3,6,9-trioxaundecane-1,11-diamine; Biotinylated PEG3 amine; EZ-Link Biotin-PEG3-Amine; Biotin-PEG3-NH2 TFA salt (common salt form)
EINECS	Contact for details

Quality Control

Our n-Biotinyl-3,6,9-Trioxaundecane-1,11-Diamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and bioconjugation applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive); desiccate during prolonged storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.