Description

5-Bromo-2,4-Difluorophenol is a halogenated difluorophenol derivative that serves as a versatile and critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents, makes it a valuable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine and bromine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorine-containing aromatic cores essential in the manufacture of high-performance electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated as a monomer or additive to impart flame retardancy, chemical resistance, and specific optical properties to advanced polymers and epoxy resins.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to create complex biaryl and heteroaryl structures.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and developing novel fluorinated compounds.

Basic Information

Product Name	5-Bromo-2,4-Difluorophenol
CAS No.	355423-48-2
Molecular Formula	C6H3BrF2O
Molecular Weight	208.99 g/mol
Synonyms	5-Bromo-2,4-difluorophenol; 2,4-Difluoro-5-bromophenol; Phenol, 5-bromo-2,4-difluoro-; 5-Brom-2,4-difluorphenol (German); 5-ブロモ-2,4-ジフルオロフェノール (Japanese); 5-溴-2,4-二氟苯酚 (Chinese); BDFP (abbreviation)
EINECS	Contact for details

Quality Control

Our 5-Bromo-2,4-Difluorophenol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its phenolic nature, it should be stored separately from strong oxidizers, bases, and acid chlorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.