Description

Spiro[7-Azabicyclo[2.2.1]Heptane-2,2-[1,3]Dioxolane] (9Ci) is a sophisticated spirocyclic organic compound featuring a bridged bicyclic amine fused with a dioxolane ring, serving as a valuable and versatile chemical building block. Its unique, rigid three-dimensional structure makes it a critical intermediate for constructing complex molecular architectures in advanced pharmaceutical research and fine chemical synthesis. This high-purity intermediate is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications requiring precise stereochemistry and functional group manipulation.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug discovery programs.
• Ligand and Catalyst Synthesis: Used to construct complex, sterically defined ligands for asymmetric catalysis and organometallic chemistry.
• Agrochemical Research: Serves as a precursor for novel herbicides, fungicides, and insecticides that benefit from its constrained geometry.
• Material Science: Potential monomer or additive for creating polymers with specific thermal or mechanical properties due to its rigid backbone.
• Academic & Industrial R&D: A valuable tool for methodological development in organic synthesis and for exploring new chemical space in medicinal chemistry.

Basic Information

Product Name	Spiro[7-Azabicyclo[2.2.1]Heptane-2,2-[1,3]Dioxolane] (9Ci)
CAS No.	355137-55-2
Molecular Formula	C8H13NO2
Molecular Weight	155.19 g/mol
Synonyms	7-Azabicyclo[2.2.1]heptane-2,2-[1,3]dioxolane, spiro; 2,8-Dioxa-5-azaspiro[3.5]nonane, 7-methyl- (8CI); Spiro(1,3-dioxolane-2,2'-7-azabicyclo[2.2.1]heptane); 7-Methyl-2,8-dioxa-5-azaspiro[3.5]nonane; 2,2-(1,3-Dioxolane)-7-azabicyclo[2.2.1]heptane; 7-Azabicyclo[2.2.1]heptane spiro-2'-(1',3'-dioxolane)
EINECS	Contact for details

Quality Control

Our Spiro[7-Azabicyclo[2.2.1]Heptane-2,2-[1,3]Dioxolane] (9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive R&D and scale-up processes. All batches are accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with ICH guidelines for impurities and can provide material meeting specific customer requirements for advanced synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.