Description

Benzotriazol-1-Yl(Cyclopropyl)Methanone is a specialized organic compound belonging to the benzotriazole class, widely recognized as a versatile reagent in advanced synthetic chemistry. Its core value lies in its role as a highly effective coupling agent and activating group, facilitating the formation of amide bonds and other challenging linkages under mild conditions. This makes it an indispensable building block for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, where precise and efficient synthesis is paramount.

Application

• Peptide Synthesis: Acts as a crucial coupling reagent (e.g., a derivative of HOBt) for the formation of peptide bonds in solid-phase and solution-phase synthesis, minimizing racemization.
• Pharmaceutical Intermediates: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing cyclopropyl or amide functionalities.
• Agrochemical Development: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific heterocyclic architectures.
• Polymer Chemistry: Employed as a monomer or modifying agent to create polymers with tailored properties for specialty coatings and engineering plastics.
• Bioconjugation: Facilitates the labeling and cross-linking of biomolecules (proteins, antibodies) for diagnostic and therapeutic applications.
• Organic Synthesis Reagent: Utilized as a general activating agent for carboxylic acids in esterification and amidation reactions within research and process chemistry.

Basic Information

Product Name	Benzotriazol-1-Yl(Cyclopropyl)Methanone
CAS No.	354996-72-8
Molecular Formula	C10H9N3O
Molecular Weight	187.20 g/mol
Synonyms	1-(Cyclopropylcarbonyl)benzotriazole; Cyclopropanecarboxylic acid benzotriazol-1-yl ester; 1H-Benzotriazol-1-yl cyclopropyl ketone; Bt-Cpr; Benzotriazole-1-carboxylic acid cyclopropyl ester; (1H-Benzotriazol-1-yl)(cyclopropyl)methanone; 1-Cyclopropylcarbonyl-1H-benzotriazole
EINECS	Contact for details

Quality Control

Our Benzotriazol-1-Yl(Cyclopropyl)Methanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR), to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect from moisture. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.