Description

4-(Piperazin-1-Yl)Benzoic Acid Dihydrochloride is a high-purity organic salt derivative of benzoic acid, featuring a piperazine moiety, which is a key structural motif in medicinal chemistry. This compound is valued for its role as a versatile synthetic intermediate and building block in the research and development of novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of complex molecules for therapeutic applications.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Chemical Research & Development: Used in academic and industrial R&D settings for exploring new chemical entities and reaction pathways in organic synthesis.
• Ligand Synthesis: Serves as a precursor for creating complex ligands used in catalysis and material science applications.
• Reference Standard: Employed as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.
• Peptidomimetic Chemistry: The benzoic acid and piperazine structure makes it useful in the design and synthesis of peptidomimetics and other bio-active molecules.

Basic Information

Product Name	4-(Piperazin-1-Yl)Benzoic Acid Dihydrochloride
CAS No.	354813-11-9
Molecular Formula	C11H16N2O2 • 2HCl
Molecular Weight	289.18 g/mol (Free base: 216.26 g/mol)
Synonyms	4-(1-Piperazinyl)benzoic acid dihydrochloride; Benzoic acid, 4-(1-piperazinyl)-, dihydrochloride; 4-Piperazin-1-yl-benzoic acid dihydrochloride; 1-(4-Carboxyphenyl)piperazine dihydrochloride; 4-Carboxyphenylpiperazine dihydrochloride; p-(Piperazin-1-yl)benzoic acid dihydrochloride
EINECS	Contact for details

Quality Control

Our 4-(Piperazin-1-Yl)Benzoic Acid Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and tests for residual solvents and heavy metals to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.