Description

3-Allyl-2-(Benzylsulfanyl)-5,6-Dihydrospiro(Benzo[H]Quinazoline-5,1'-Cyclohexane)-4(3H)-One is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic quinazoline core. This compound is valued for its unique molecular architecture, which makes it a critical building block in modern medicinal chemistry research and development. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents, particularly for applications in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates targeting specific biological pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Oncology Drug Development: Serves as a building block for potential kinase inhibitors and other targeted cancer therapies.
• CNS-Active Compound Synthesis: Employed in the research and development of potential neuroprotective agents or modulators of neurological receptors.
• Chemical Biology Probe Development: Utilized to create tool compounds for investigating protein function and cellular signaling mechanisms.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	3-Allyl-2-(Benzylsulfanyl)-5,6-Dihydrospiro(Benzo[H]Quinazoline-5,1'-Cyclohexane)-4(3H)-One
CAS No.	353787-50-5
Molecular Formula	C28H30N2OS
Molecular Weight	442.62 g/mol
Synonyms	3-Allyl-2-(benzylthio)-5,6-dihydrospiro[benzo[h]quinazoline-5,1'-cyclohexan]-4(3H)-one; Spiro[benzo[h]quinazoline-5,1'-cyclohexane]-4(3H)-one, 3-allyl-2-(benzylthio)-5,6-dihydro-; 353787-50-5; Allyl-benzylsulfanyl-dihydrospirobenzoquinazolinone; Advanced spiroquinazoline intermediate
EINECS	Contact for details

Quality Control

Every batch of 3-Allyl-2-(Benzylsulfanyl)-5,6-Dihydrospiro(Benzo[H]Quinazoline-5,1'-Cyclohexane)-4(3H)-One is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with stringent internal specifications suitable for research and development use. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials and sources of ignition. For long-term storage, consider storage under an inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.