Description

3-(4-Chloro-2-Fluoro-5-Sulfanylphenyl)-1-Methyl-6-(Trifluoromethyl)-1,2,3,4-Tetrahydropyrimidine-2,4-Dione is a high-purity, advanced pharmaceutical intermediate characterized by its unique tetrahydropyrimidine-2,4-dione core. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with targeted therapeutic effects. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of new drugs, particularly in areas such as oncology and virology.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and production of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead compound optimization and structure-activity relationship (SAR) studies for new drug candidates.
• Oncological Drug Development: Serves as a core scaffold for the synthesis of potential anti-cancer agents targeting specific cellular pathways.
• Antiviral Agent Synthesis: Employed in the development of new antiviral compounds, leveraging its fluorinated and heterocyclic structure.
• Chemical Biology Probes: Utilized in the creation of specialized probes for studying enzyme function and biological mechanisms.
• Custom Synthesis & Contract Manufacturing: A vital starting material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke molecules for clinical trials.

Basic Information

Product Name	3-(4-Chloro-2-Fluoro-5-Sulfanylphenyl)-1-Methyl-6-(Trifluoromethyl)-1,2,3,4-Tetrahydropyrimidine-2,4-Dione
CAS No.	353292-92-9
Molecular Formula	C12H7ClF4N2O2S
Molecular Weight	354.71 g/mol
Synonyms	1-Methyl-6-(trifluoromethyl)-3-(4-chloro-2-fluoro-5-mercaptophenyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione; 3-(4-Chloro-2-fluoro-5-mercaptophenyl)-1-methyl-6-(trifluoromethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione; 1,2,3,4-Tetrahydropyrimidine-2,4-dione, 3-(4-chloro-2-fluoro-5-mercaptophenyl)-1-methyl-6-(trifluoromethyl)-; CAS 353292-92-9; 353292-92-9
EINECS	Contact for details

Quality Control

Our 3-(4-Chloro-2-Fluoro-5-Sulfanylphenyl)-1-Methyl-6-(Trifluoromethyl)-1,2,3,4-Tetrahydropyrimidine-2,4-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are provided to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.