Description

Ethyl (6-Bromo-4-Phenyl-2-(3,4,5-Trimethoxyphenyl)-3(4H)-Quinazolinyl)Acetate is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 353253-21-1. This compound is valued for its complex heterocyclic structure, which serves as a critical building block in modern medicinal chemistry research and development. It is primarily sought by R&D laboratories and pharmaceutical manufacturers focused on synthesizing novel therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel quinazolinone-based drug candidates with potential biological activity.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity against specific biological targets.
• Oncology Drug Development: Employed in the research of potential kinase inhibitors and other anti-cancer agents due to its privileged quinazolinone core.
• CNS-Active Compound Synthesis: Serves as a building block for developing potential therapeutics for neurological disorders.
• Chemical Biology Probes: Utilized in the creation of tool compounds for studying enzyme function and cellular pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and early-stage API development.

Basic Information

Product Name	Ethyl (6-Bromo-4-Phenyl-2-(3,4,5-Trimethoxyphenyl)-3(4H)-Quinazolinyl)Acetate
CAS No.	353253-21-1
Molecular Formula	C27H25BrN2O5
Molecular Weight	537.41 g/mol
Synonyms	Ethyl 2-(6-bromo-4-phenyl-2-(3,4,5-trimethoxyphenyl)-4H-quinazolin-3-yl)acetate; 353253-21-1; Quinazolinyl Acetate Derivative; 6-Bromo-4-phenyl-2-(3,4,5-trimethoxyphenyl)-3(4H)-quinazolinylacetic Acid Ethyl Ester; Ethyl [6-Bromo-4-Phenyl-2-(3,4,5-Trimethoxyphenyl)-4H-Quinazolin-3-yl]acetate; BR-QUIN-TMPA-OEt
EINECS	Contact for details

Quality Control

Our Ethyl (6-Bromo-4-Phenyl-2-(3,4,5-Trimethoxyphenyl)-3(4H)-Quinazolinyl)Acetate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and full analytical data is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 97.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.