Description

1-Fmoc-Piperazine Hydrobromide is a high-purity, protected piperazine derivative essential for advanced organic synthesis and pharmaceutical research. This compound serves as a critical building block for the solid-phase and solution-phase synthesis of complex molecules, particularly peptides and peptidomimetics. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers engaged in drug discovery and the production of active pharmaceutical ingredients (APIs).

Application

• Peptide Synthesis: A key intermediate for introducing the piperazine moiety into peptide chains using Fmoc-strategy solid-phase peptide synthesis (SPPS).
• Pharmaceutical Intermediates: Serves as a versatile building block in the research and development of novel drug candidates, including kinase inhibitors and GPCR-targeted therapies.
• Chemical Biology Probes: Used in the synthesis of labeled compounds and molecular probes for studying biological pathways and protein interactions.
• Combinatorial Chemistry: A valuable scaffold for generating diverse chemical libraries in high-throughput screening for drug discovery.
• Linker and Spacer Chemistry: Employed in the design and synthesis of bioconjugates, antibody-drug conjugates (ADCs), and polymer-supported reagents.
• Fine Chemical Synthesis: Acts as a precursor for other functionalized piperazine derivatives used in various specialty chemical applications.

Basic Information

Product Name	1-Fmoc-Piperazine Hydrobromide
CAS No.	352351-60-1
Molecular Formula	C19H21BrN2O2
Molecular Weight	389.29 g/mol
Synonyms	1-(9H-Fluoren-9-ylmethoxycarbonyl)piperazine hydrobromide; Fmoc-Piperazine·HBr; N-α-Fmoc-piperazine hydrobromide; 1-Fmoc-piperazine HBr; Piperazine, 1-[(9H-fluoren-9-ylmethoxy)carbonyl]-, hydrobromide; 1-[(9H-Fluoren-9-ylmethoxy)carbonyl]piperazine Hydrobromide; 1-(Fmoc)piperazine Hydrobromide; 1-Fmoc-Piperazine Hydrobromide Salt
EINECS	Contact for details

Quality Control

Our 1-Fmoc-Piperazine Hydrobromide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and cGMP applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. The container should be kept tightly sealed and allowed to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.