Description

n-Fmoc-1,4-Butanediamine Hydrobromide is a protected diamine building block essential for solid-phase peptide synthesis (SPPS) and other organic synthesis applications. This compound provides a crucial amine functionality protected by the base-labile 9-fluorenylmethoxycarbonyl (Fmoc) group, enabling controlled deprotection and sequential chain elongation. It is primarily used by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries for the development of peptide-based therapeutics, diagnostic agents, and novel materials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled introduction of a 1,4-diaminobutane (putrescine) spacer or linker into peptide sequences using Fmoc chemistry protocols.
• Linker and Spacer Chemistry: Used to incorporate a flexible, four-carbon chain between functional groups in the synthesis of peptide-drug conjugates, bioconjugates, and labeled biomolecules.
• Protecting Group Strategy: Serves as a protected diamine synthon in multi-step organic synthesis, where selective deprotection of the Fmoc group is required.
• Combinatorial Library Synthesis: Employed in the generation of diverse compound libraries for drug discovery and high-throughput screening campaigns.
• Polyamide and Polymer Synthesis: Acts as a monomer or chain extender in the preparation of specialized polyamides and other polymers requiring diamine components.
• Bioconjugation and Probe Development: Facilitates the attachment of peptides to surfaces, nanoparticles, fluorophores, or other molecules for diagnostic and research applications.

Basic Information

Product Name	n-Fmoc-1,4-Butanediamine Hydrobromide
CAS No.	352235-99-5
Molecular Formula	C20H25BrN2O2
Molecular Weight	405.33 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1,4-butanediamine hydrobromide; Nα-Fmoc-1,4-diaminobutane hydrobromide; N-Fmoc-putrescine hydrobromide; 4-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]butylamine hydrobromide; Fmoc-Dab(Boc)-OH hydrobromide salt (related); Fmoc-4-Aminobutylamine HBr; N-(9-Fluorenylmethoxycarbonyl)-1,4-butanediamine HBr
EINECS	Contact for details

Quality Control

Our n-Fmoc-1,4-Butanediamine Hydrobromide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.