Description

cis-(Z)-8-Amino-Cyclooct-4-Enecarboxylic Acid Hydrochloride is a specialized, high-purity organic building block featuring a unique conformationally constrained cyclooctene scaffold with an amino acid functional group. This compound is of significant value in advanced pharmaceutical research and development, particularly for the synthesis of novel peptide mimetics and bioactive macrocycles. It serves as a critical intermediate for medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and agrochemical industries seeking to explore new chemical space and modulate biological activity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel peptide-based drugs and constrained peptidomimetics targeting GPCRs and other protein classes.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to introduce conformational rigidity into lead compounds, potentially improving potency and metabolic stability.
• Macrocyclic Compound Synthesis: Serves as a precursor for the construction of medium-sized rings (8-10 membered) in drug discovery programs, a valuable scaffold in modern medicinal chemistry.
• Chemical Biology Probes: Utilized in the development of activity-based probes and affinity labels for studying enzyme mechanisms and protein function.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents with novel modes of action.
• Academic & Contract Research: Employed in university and CRO settings for fundamental research in organic synthesis methodology and new material development.

Basic Information

Product Name	cis-(Z)-8-Amino-Cyclooct-4-Enecarboxylic Acid Hydrochloride
CAS No.	350015-75-7
Molecular Formula	C9H16ClNO2
Molecular Weight	205.68 g/mol
Synonyms	(Z)-8-Aminocyclooct-4-ene-1-carboxylic acid hydrochloride; 8-AZA-cyclooct-4-ene-1-carboxylic acid, hydrochloride; cis-8-Aminocyclooct-4-enecarboxylic acid HCl; (1Z,5Z)-8-Aminocyclooct-4-ene-1-carboxylic acid hydrochloride; 8-Amino-cyclooct-4-ene-carboxylic acid hydrochloride (cis); Cyclooct-4-ene-1-carboxylic acid, 8-amino-, hydrochloride, (1Z,5Z)-; 350015-75-7
EINECS	Contact for details

Quality Control

Our cis-(Z)-8-Amino-Cyclooct-4-Enecarboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency, meeting the stringent requirements of research and development applications. Certificates of Analysis (COA) detailing HPLC purity, chiral purity (if applicable), NMR, and mass spectrometry data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.