Description

4-[(6,7-Dimethoxyquinolin-4-Yl)Oxy]-3-Fluoroaniline is a high-purity, advanced pharmaceutical intermediate characterized by its quinoline-based molecular structure. This compound is of significant commercial importance for its role in the synthesis of targeted therapeutic agents, particularly kinase inhibitors. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel drug candidates for oncology and other therapeutic areas.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of small-molecule kinase inhibitors for cancer therapy.
• Research & Development: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Preclinical Development: Serves as a critical raw material for producing active pharmaceutical ingredients (APIs) in the preclinical and early clinical trial stages.
• Chemical Synthesis: Utilized in organic synthesis to introduce the specific quinoline-fluoroaniline pharmacophore into more complex molecular architectures.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of investigational new drugs.

Basic Information

Product Name	4-[(6,7-Dimethoxyquinolin-4-Yl)Oxy]-3-Fluoroaniline
CAS No.	347161-74-4
Molecular Formula	C₁₇H₁₅FN₂O₃
Molecular Weight	314.31 g/mol
Synonyms	3-Fluoro-4-[(6,7-dimethoxy-4-quinolyl)oxy]aniline; 4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-3-fluoro-benzenamine; 3-Fluoro-4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline; 4-((6,7-Dimethoxyquinolin-4-yl)oxy)-3-fluoroaniline; CAS 347161-74-4; Quinoline-fluoroaniline intermediate; 6,7-Dimethoxy-4-(3-fluoro-4-aminophenoxy)quinoline
EINECS	Contact for details

Quality Control

Our production of 4-[(6,7-Dimethoxyquinolin-4-Yl)Oxy]-3-Fluoroaniline adheres to stringent quality management protocols to ensure batch-to-batch consistency and purity suitable for pharmaceutical research. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support development needs with material produced under quality systems aligned with cGMP principles for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.