Description

tert-Butyl 8-Bromoquinolin-3-Ylcarbamate is a high-purity, advanced pharmaceutical intermediate characterized by its brominated quinoline core protected with a tert-butyl carbamate group. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with potential therapeutic activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for oncology and antiviral applications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel quinoline-based drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new chemical entities.
• Organic Synthesis Building Block: Serves as a versatile substrate for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and further functionalization due to the reactive bromine atom and protected amine.
• API Development: Employed in the research and scale-up stages for developing potential Active Pharmaceutical Ingredients, especially in oncology and infectious disease research.
• Chemical Biology Probes: Can be utilized to create molecular probes for studying biological processes and target identification.

Basic Information

Product Name	tert-Butyl 8-Bromoquinolin-3-Ylcarbamate
CAS No.	347146-17-2
Molecular Formula	C₁₄H₁₅BrN₂O₂
Molecular Weight	323.19 g/mol
Synonyms	8-Bromo-3-[[(1,1-dimethylethoxy)carbonyl]amino]quinoline; tert-Butyl N-(8-bromoquinolin-3-yl)carbamate; 3-((tert-Butoxycarbonyl)amino)-8-bromoquinoline; 8-Bromo-3-((tert-butoxycarbonyl)amino)quinoline; 8-Bromoquinolin-3-yl-carbamic acid tert-butyl ester; tert-Butyl (8-bromoquinolin-3-yl)carbamate; BOC-8-Bromo-3-aminoquinoline; 8-Bromo-3-Boc-aminoquinoline
EINECS	Contact for details

Quality Control

Our tert-Butyl 8-Bromoquin-3-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with key parameters including assay (HPLC), related substances, and residual solvents. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.